Longevity – Reversing senescence
Counteract cell ageing – with senolytics and senorevertics
Dr. med. Heinz Lüscher
Who wouldn’t want to live a long and, above all, healthy life? The extent to which discomfort and frailty limit us with increasing age is determined, among other things, by senescent, dysfunctional cells in our body. These cause us to age faster and lead to various (age-related) diseases. These processes can be counteracted with so-called senotherapeutics, which can be divided into senolytics and senorevertics. These products contain very special natural substances.
Senotherapeutics
Senotherapeutics are substances that are used to specifically combat cell ageing. By treating senescent cells, degenerative diseases can be alleviated or prevented and health can be increased during the remaining lifetime. Senolytics work to eliminate senescent cells, while senorevertics aim to reverse the senescence process, restore senescent cells to health and promote the development of new, healthy cells.
What are senescent cells?
Senescent cells are dysfunctional cells that form with increasing age or in organs affected by chronic diseases (cell aging). They can also develop in response to injury (including surgery), environmental stress (toxins) or cancerous mutations. They can release toxic substances and damage surrounding tissue, leading to inflammation, for example. Normally, such cells are eliminated by the immune system, but with increasing age or chronic diseases this works less well. Senescent cells can therefore remain in the body for a very long time and contribute to further signs of ageing and chronic diseases. Senescent cells are associated with a variety of degenerative age-related diseases.
What are senolytics?
The term senolytics is derived from senescence and lysis. Senescence (Latin senescere = to age) has to do with ageing, but is not a synonym for it. It can be defined as an age-related increase in mortality (death rate) and a decrease in fertility (fecundity). One could paraphrase that senescence is the degenerative part of ageing. “Lysis” means dissolution, dissolution or separation in general and in biology specifically the breakdown of a cell by dissolution of the cell membrane. Senolytics are substances that can cause the dissolution of senescent cells, with the aim of counteracting the ageing process or age-related diseases, i.e. extending the health span (not the life span).
What are senorevertics?
Senorevertics are not primarily aimed at eliminating senescent cells. Their mechanism is to reverse the senescent state of the cells, restore their functionality and enable their reintegration into the tissue. This approach supports the idea that the reversion of these cells to a non-senescent, quiescent (repairable) or fully functional state can mitigate the adverse effects of cellular senescence without the need for complete cell removal.
Combination of senolytics and senorevertics
Recently, a new approach to combating senescence-related diseases was discovered and a patent application was filed. It is a two-phase treatment:
- In phase 1, a senolytic formulation is used to selectively eliminate senescent cells (reset). It is a synergistic combination of naturally occurring flavonols and a broader family of lignans. Both substance classes together mutually reinforce the senolytic potential.
- In phase 2, a senoreverting formulation is used to rejuvenate the tissues affected by senescence (Renew). The approach utilizes the power of triterpenes in combination with amino acid derivatives or small peptides that can reverse senescence. This combination targets cellular pathways involved in the repair and regeneration of senescent cells.
Advantages of combination therapy
The advantages of the combination therapy of senolytics and senorevertics are as follows:
- Addresses several causes of senescence and the associated loss of health.
- Harnesses the power of natural compounds while overcoming the limitations of their isolated use through carefully developed synergistic formulations.
- Provides a novel combination of senolytic and senoreversive effects.
- Promising approach to alleviating a variety of age-related health disorders and possibly extending healthy lifespan.
Combination therapy can be used to treat and prevent a wide range of chronic, degenerative and age-related diseases, such as
- Cardiovascular diseases
- Metabolic disorders
- Neurodegenerative diseases (e.g. dementia, Parkinson’s disease)
- Diseases of the musculoskeletal system (e.g. arthrosis)
- Skin ageing
- Immune disorders, autoimmune diseases
- Loss of muscle mass and bone density
- Chronic inflammation
- Cancer
What is senescence?
Cellular senescence, a key feature of ageing, is a condition in which cells permanently stop dividing but remain metabolically active. The ability of the immune system to eliminate senescent cells decreases over time, leading to their accumulation in the tissue. These senescent cells secrete pro-inflammatory factors, creating a chronic inflammatory environment that damages neighboring cells and accelerates age-related tissue dysfunction.
Recommended product
I recommend a product which, in a box containing two different preparations, does not necessarily aim to increase longevity, but rather the health span. However, the two products are also available separately. One product eliminates senescent cells (“Reset”), the other supports the body in the formation of new, healthy cells (“Renew”). The two products are taken one after the other for one month; the box therefore lasts for two months.
Recommended intake
Both products contain 60 capsules, of which 2 capsules are taken daily (1 in the morning, 1 in the evening). You start with the “Reset” product (duration of intake: 1 month), followed by the “Renew” product (also for one month). The cure can be repeated at any time if necessary or taken permanently.
Further articles on the topic of longevity
Boosting mitochondrial health – The role of nicotinamide riboside (NR) and ergothioneine (EGT)
Active ingredients to reduce AGEs
Further information
Longevity; basics, nutrition, exercise, active ingredients:
https://longevity-advice.com/
SenoFree® (senolytic):
https://senofree.net/
SenoXure® (senorevertic):
https://senoxure.net/
